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doi: 10.1016/j.ejphar.2020.173551 417 AlkafaasSSAbdallahAMGhoshSLoutfySAElkafasSSAbdel FattahNFet al

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H.CampisiR.DorseyD.PriorJ

Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation

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Specifically, the use of chemotherapy drugs resulted in elevated levels of ALT and AST, and an increase in the severity of side effects such as nausea and vomiting, contributing to high GSH intake